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KMID : 0363320060270040915
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 4 p.915 ~ p.926
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Neuroprotective Effect Yanggyuksanhwa-tang on Cerebral Infarction Induced by MCAO in Hyperlipidemic Rats
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Oh Kyung-Hwan
Lee Won-Chul
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Abstract
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Objectives : Yanggyuksanhwa-tang is a prescription used for cerebral infarction clinically it is known that this formula reduces body fat, serum cholesterol and triglyceride in hyperglycemia and obesity patients. According to previous research data, controlling these types of lipid is considered to decrease the risk of cerebral infarction. Based on this fact, we investigated the relationship between hyperlipidemia and cerebral infarction, and the effect of Yanggyuksanhwa-tang on hyperlipidemic cerebral infarction.
Methods : We induced cerebral infarction by middle cerebral artery occlusion (MCAO) in high-fat diet rats, and the rats were administered Yanggyuksanhwa-tang.
Results : Infarct area and serum lipid were measured, and the level of elements such as c-Fos, Bax and caspase-3 in penumbra of infarct were expressed by immunohistochemical staining.
Conclusions : Yanggyuksanhwa-tang showed neuroprotective effect through preventing neuronal cell apoptosis as well as reducing serum lipid level in hyperlipidemic condition.
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KEYWORD
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Yanggyuksanhwa-tang, hyperlipidemic condition, MCAO, infarct volume, neuroprotective effect
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